Deletion and intrachromosomal recombinations were observed to be induced at the two highest concentrations. [10] The quality of the product can be assessed by titration with indigo. Seiler (1977) found no inhibition of the incorporation of [3H]thymidine into testicular DNA due to thiourea in vivo using the Friedman-Staub test (Friedman & Staub, 1976). Govers H, Ruepert C, Stevens T, Van Leeuwen C (1986) Experimental determination and prediction of partition coefficients of thioureas and their toxicity to Photobacterium phosphoreum. Twenty-seven female lambs (2–3 months old) were orally administered 0 or 50 mg thiourea/kg body weight daily for 2, 4, or 6 months (six treated and three controls per group) (Nasseri & Prasad, 1987a; see section 8.7.2). Journal of Clinical Investigation, 26:446–452. Dooms-Goossens A, Chrispeels MT, de Veylder H, Roelandts R, Willems L, Degreef H (1987) Contact and photocontact sensitivity problems associated with thiourea and its derivatives: a review of the literature and case reports. Teratology, 13:263–266. The thyroid gland was moderately to severely enlarged, although there was no direct correlation with length of dosing. Half-lives of 17 days and 2.4 h can be calculated for the hydrosphere and the atmosphere, respectively. (1984) obtained accumulation factors in the range of <10–90 for golden orfe (Leuciscus idus), algae (Chlorella fusca), and activated sludge. Según los datos sobre su uso como depresor del tiroides, <15 mg de tiourea/día (<0,2 mg/kg de peso corporal al día) no tuvieron ningún efecto, mientras que 70 mg/día (alrededor de 1,0 mg/kg de peso corporal al día) sí lo tuvieron. Weast R, Astle M, eds. Hazleton (1987) 13-week drinking water study in rats with thiourea. Journal of Veterinary Medicine, Series B, 47(9):641–652. Rats received, over a 2-week period, 0.05% thiourea (25 mg/kg body weight per day) up to 2% thiourea (1000 mg/kg body weight per day) in food. In several studies involving different strains of mice, thyroid hyperplasia, but not thyroid tumours, was reported after oral administration. Sathyanesan A, Joy K, Kulkarni R (1978) Endocrine changes in fishes in response to pollutants. Diplomarbeit im Fachbereich Chemie der Fachhochschule Aalen, pp. Due to the measured soil sorption coefficients and the observed (slow) biodegradation in soil, accumulation of thiourea in the geosphere is not to be expected. DeForge LE, Fantone JC, Kenney JS, Remick DG (1992) Oxygen radical scavengers selectively inhibit interleukin 8 production in human whole blood. Some cases showed increased sensitivity to UV light (photocontact dermatitis). Histopathology of the thyroid gland revealed hyperplasia of the follicle-lining epithelial cells that project into the lumen. Induction of pulmonary oedema was observed by a significant increase in the ratio of lung weight to body weight in all three groups of experimental rats. Weinheim, Wiley-VCH, pp. * Wear protective work clothing. Dermal contact from the cleaning process could be relevant for those occupationally exposed. A PNEC for surface waters may be calculated by dividing the lowest valid NOEC obtained in chronic studies by an appropriate uncertainty or characterization factor: PNEC = (0.25 mg/litre)/50 = 0.005 mg/litre. Stelzner TJ, Welsh CH, Berger E, McCullough RG, Morris K, Repine JE, Wel JV (1987) Antiarrhythmic agents diminish thiourea-induced pulmonary vascular protein leak in rats. Il a été procédé en novembre 2001 à un dépouillement bibliographique exhaustif des bases de données existantes afin de rechercher des références à des publications postérieures à celles qui sont citées dans les rapports en question. In water, thiourea is resistant to hydrolysis. R 6264). Les prises supportables devraient être très inférieures à 0,07 mg de thiourée par kg de poids corporel et par jour. controls: 4 x 50 The effect was correlated with catalase inhibition which facilitates H 2 O 2 mediated oxidation of NADPH that acts as oxidant in pentose pathway to produce glucose (Hendricks and Taylorson, 1975). En otro estudio de exposición profesional con datos medidos a partir de la producción y el envasado de tiourea se notifica una concentración media en el aire (tiourea en el polvo total) de 0,085 mg/m3 (máximo 0,32 mg/m3). Acta Pharmacologica et Toxicologica, 32:358–368. Stuttgart, S. Hirzel, Wissenschaftliche Verlagsgesellschaft (BUA Report 179). Pour caractériser le risque, on a comparé les données tirées de l’étude russe mentionnée ci-dessus à la concentration atmosphérique moyenne (de thiourée dans les poussières totales) de 0,085 mg/m3 et à la concentration maximale de 0,32 mg/m3 mesurées dans une usine allemande. 0.25 mg/litre is the lowest valid NOEC from a 21-day reproduction test with. Basándose en los resultados válidos de pruebas disponibles sobre la toxicidad de la tiourea para diversos organismos acuáticos, se puede clasificar como producto de toxicidad entre moderada y alta para el compartimento acuático. Journal of the National Cancer Institute, 7:159. The quantity of thiourea present in the stratum corneum of the application area was measured by liquid scintillation counting after tape-stripping the treated area (Rougier et al., 1983). A single intraperitoneal dose of 125 mg thiourea/kg body weight administered to mice led to a weak increase in mutation rate (up to a factor of 3.6) in Salmonella strains TA 1530 and TA 1538 in a host-mediated assay, but negative results were obtained in Saccharomyces cerevisiae following a single intraperitoneal dose of 1000 mg/kg body weight. Friesel et al. Thiourea dioxide has also been used for the reduction of aromatic nitroaldehydes and nitro ketones to nitroalcohols. Son pocos los datos que hay sobre los niveles de exposición en el lugar de trabajo. Overall, therefore, thiourea is not classifiable as to its carcinogenicity to humans (Group 3). Twenty-two per cent of an initial concentration of 1.5 g/litre was degraded within 1 week and 96% within 15 weeks of incubation. The lumina were devoid of colloid. An investigation at a textile factory on the prevalence of hypothyroidism gave typical concentrations of 5 µg thiourea/m3 at an inlet of the local exhaust ventilation of the finishing machines. Contact Dermatitis, 11:124. For the terrestrial compartment, toxicity tests on microorganisms, higher plants, earthworms, nematodes, and insects are available. Numerous tests have been performed on the biodegradability of thiourea. Glazer & Orion (1984) investigated the effects of thiourea on the development of nematodes. Il n’est pas exclu que la thiourée puisse passer du sol aux eaux souterraines par lessivage, en particulier lorsque les conditions ne sont pas favorables à une biodégradation. Environmental and Molecular Mutagenesis, 24:143–147. The accuracy of the occupational exposure data (Talakin et al., 1985) is uncertain. American Journal of Contact Dermatitis, 3:37–39. For the BUA review process, the company that is in charge of writing the report (usually the largest manufacturer in Germany) prepares a draft report using literature from an extensive literature search as well as internal company studies. Bhide M (1991) Thiourea as a xenobiotic, showing its adverse effects on mortality, behaviour and metamorphosis and on histopathological and cytological changes in the developing ovaries of Dysdercus similis. Talakin YUN, Kolornoiskaya M, Meleknin UD, Grishina KA, Chernykh LY, Kondratenko LA (1985) Functional status of the thyroid gland of workers employed in thiourea manufacture.

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